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USMLE.Step1.InfectiousDiseases.Malaria Medical · USMLE

Malaria chemoprophylaxis — first-line regimens

Node 7 of 15 in USMLE

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  • Identify the key rules and §§ that apply to malaria chemoprophylaxis — first-line regimens.
  • Apply the USMLE.Step1.InfectiousDiseases.Malaria knowledge element in a typical exam scenario.
  • Recognize common distractors and partial-credit answers.

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USMLE.Step1.InfectiousDiseases.Malaria

Malaria chemoprophylaxis — first-line regimens

Step 1 · Infectious Diseases CDC Yellow Book 2026 · Malaria

Atovaquone-proguanil, doxycycline, and mefloquine are preferred first-line agents for most regions where chloroquine resistance is present. Atovaquone-proguanil is taken 1–2 days before entry through 7 days after departure; doxycycline 1–2 days before through 28 days after; mefloquine ≥2 weeks before through 4 weeks after. Primaquine has a role against P. vivax / P. ovale when G6PD status has been confirmed.

CDC Yellow Book 2026 · Malaria FDA label · atovaquone-proguanil

Check yourself

3 quick questions — no score kept, just formative feedback.

  1. Q1 · USMLE.Step1.CV

    A 62-year-old has chest pain radiating to the jaw and ST elevations in leads V2-V5. Door-to-balloon time guideline for primary PCI per ACC/AHA STEMI guidelines is:

    Answer choices
  2. Q2 · USMLE.Step1.Micro

    Per the CDC Pink Book, which vaccine is LIVE-ATTENUATED and contraindicated in pregnancy and severe immunocompromise?

    Answer choices
  3. Q3 · USMLE.Step1.Renal

    A patient with severe hyperkalemia (K+ 7.2) and peaked T waves on ECG. The first intervention to stabilize the cardiac membrane is:

    Answer choices

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